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Title:Exhaled volatile organic compounds and respiratory disease : recent progress and future outlook
Authors:ID Magnano, Maria Chiara (Author)
ID Ahmed, Waqar (Author)
ID Wang, Ran (Author)
ID Bergant Marušič, Martina (Author)
ID Fowler, Stephen J. (Author)
ID White, Iain R. (Author)
Files:.pdf 1-s2.0-S016599362400222X-main.pdf (1,36 MB)
MD5: 26E6DCC9F6ED8797D00842F57383BE79
Work type:Unknown
Typology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:The theoretical basis of eVOCs as biomarkers for respiratory disease diagnosis is described, followed by a review of the potential biomarkers that have been proposed as targets from in vitro studies. The utility of these targets is then discussed based on comparison with results from clinical breath studies. The current status of breath research is summarised for various diseases, with emphasis placed on quantitative and targeted studies. Potential for bias highlights several important concepts related to standardization, including practices adopted for compound identification, correction for background inspired VOC levels and computation of mixing ratios. The compiled results underline the need for targeted studies across different analytical platforms to understand how sampling and analytical factors impact eVOC quantification. The impact of environmental VOCs as confounders in breath analysis is discussed alongside the potential that eVOCs have as biomarkers of air pollution exposure and future perspectives on clinical breath sampling are provided.
Keywords:breath analysis, disease diagnosis, exhaled volatile organic compounds, respiratory disease, environmental exposure analysis, breath analysis
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2024
Year of publishing:2024
Number of pages:str. 1-14
Numbering:Vol. 176, [article no.] ǂ117739
PID:20.500.12556/RUNG-9004-2f27ec28-a5c7-99f9-0251-426e60eacf8f New window
COBISS.SI-ID:194499075 New window
ISSN on article:0165-9936
DOI:10.1016/j.trac.2024.117739 New window
Publication date in RUNG:06.05.2024
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Record is a part of a journal

Title:TrAC : Trends in analytical chemistry
Shortened title:TrAC, Trends anal. chem.
COBISS.SI-ID:26556928 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Funding programme:Raziskovalni in infrastrukturni programi ARIS
Project number:P1-0034
Name:Analitika in kemijska karakterizacija materialov ter procesov


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.