Repozitorij Univerze v Novi Gorici

Statistika RUNG
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Največkrat ogledana gradiva tedna (zadnjih 7 dni).

Investigation of the effective transmittance of Mach-Zehnder interferometer in the multi-longitudinal-mode high-spectral-resolution lidar
Fei Gao, Fengjia Gao, Xiao Yang, Gaipan Li, Li Wang, Meng Wang, Dengxin Hua, Griša Močnik, Samo Stanič, 2022

Opis: Effective transmittance is an important parameter of Mach-Zehnder interferometer in the retrieval of aerosol optical properties using the multi-longitudinal-mode high-spectral-resolution lidar, which is a function of the complex degree of coherence. In this paper, we retrieve the parameter of the complex degree of coherence for the multi-longitudinal-mode laser from the theoretical analysis, optical simulation and experimental measurements, which are 0.726, 0.678 and 0.453 using the Mach-Zehnder interferometer with the optimal optical path difference of two times of laser optical cavity length (∼1000 mm) and under the light illumination of the high power Nd:YAG laser with the mode number of 101 and mode interval of 300 MHz under the condition of laser linewidth of 1 cm−1 (30 GHz). The preliminary measurement results of aerosol optical properties using the constructing multi-longitudinal-mode high-spectral-resolution lidar show that the difference of the complex degree of coherence retrieved from the presented methods results in the relative error of 40% in the aerosol backscattering coefficient with thin cloud layer and 90% with the presence of dense aerosol layer.
Ključne besede: effective transmittance, Mach-Zehnder interferometer, Multi-logitudinal-mode laser, High-spectral-resolution lidar
Objavljeno: 20.09.2022; Ogledov: 58; Prenosov: 0
.pdf Polno besedilo
Ogledov v tednu: 58

Analysis of gambling slot machines
Marko Žagar, 2022

Ključne besede: probability theory, statistics, combinatorics, slot machine games
Objavljeno: 16.09.2022; Ogledov: 87; Prenosov: 0
.pdf Polno besedilo
Ogledov v tednu: 50

Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion
Gulshan Walke , Jana Aupič , Hadeel Kashoua , Pavel Janoš , Shelly Meron , Yulia Shenberger , Zena Qasem , Lada Gevorkyan-Airapetov , Alessandra Magistrato , Sharon Ruthstein , 2022

Opis: Abnormal cellular copper levels have been clearly implicated in genetic diseases, cancer, and neurodegeneration. Ctr1, a high-affinity copper transporter, is a homotrimeric integral membrane protein that provides the main route for cellular copper uptake. Together with a sophisticated copper transport system, Ctr1 regulates Cu(I) metabolism in eukaryotes. Despite its pivotal role in normal cell function, the molecular mechanism of copper uptake and transport via Ctr1 remains elusive. In this study, electron paramagnetic resonance (EPR), UV-visible spectroscopy, and all-atom simulations were employed to explore Cu(I) binding to full-length human Ctr1 (hCtr1), thereby elucidating how metal binding at multiple distinct sites affects the hCtr1 conformational dynamics. We demonstrate that each hCtr1 monomer binds up to five Cu(I) ions and that progressive Cu(I) binding triggers a marked structural rearrangement in the hCtr1 C-terminal region. The observed Cu(I)-induced conformational remodeling suggests that the C-terminal region may play a dual role, serving both as a channel gate and as a shuttle mediating the delivery of copper ions from the extracellular hCtr1 selectivity filter to intracellular metallochaperones. Our findings thus contribute to a more complete understanding of the mechanism of hCtr1-mediated Cu(I) uptake and provide a conceptual basis for developing mechanism-based therapeutics for treating pathological conditions linked to de-regulated copper metabolism.
Ključne besede: ctr1, copper, epr, molecular dynamics
Objavljeno: 15.09.2022; Ogledov: 102; Prenosov: 0
.pdf Polno besedilo
Ogledov v tednu: 47

Proces izdelave izdelka z računalniško numerično vodenim orodjem
Anita Petkovska, 2022

Opis: V diplomskem delu je predstavljen tehnološki vidik izdelave izdelka z uporabo tehnologije računalniških numerično vodenih (CNC) laserskih naprav, kot primer avtomatsko vodenega orodja, ki se danes pogosto uporablja v proizvodnem procesu. Namen diplomskega dela je opisati tehnologijo CNC in izpeljati projekt izdelave od povpraševanja do odpreme izdelka. Z opisom CNC laserskih strojev smo ugotovili njihov način delovanja, njihove osnovne komponente ter načine vodenja. Za obdelovalni stroj, na katerem je bil izveden projekt izdelave izdelka, smo izbrali laserski rezalnik in nato opisali njegove sestavne dele in zgodovino razvoja ter tipe laserskih rezalnikov. Za konkretni projekt izdelave knjižnega stojala smo opisali vse proizvodne procese, pri katerih uporabljamo stroj za lasersko obdelovanje materiala. V opisu te izvedbe smo prikazali zaporedje in odločitve v postopku proizvodnje.
Ključne besede: Računalniško numerično vodenim orodjem, laserski rezalnik, tehnologija rezanja, NC program, gnezdenje
Objavljeno: 16.09.2022; Ogledov: 80; Prenosov: 2
.pdf Polno besedilo
Ogledov v tednu: 45

The conformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter
Alessandra Magistrato , Sharon Ruthstein , Jana Aupič , Pavel Janoš , 2022

Opis: Copper is a trace element vital to many cellular functions. Yet its abnormal levels are toxic to cells, provoking a variety of severe diseases. The high affinity copper transporter 1 (CTR1), being the main in-cell copper [Cu(I)] entry route, tightly regulates its cellular uptake via a still elusive mechanism. Here, all-atoms simulations unlock the molecular terms of Cu(I) transport in eukaryotes disclosing that the two methionine (Met) triads, forming the selectivity filter, play an unprecedented dual role both enabling selective Cu(I) transport and regulating its uptake rate thanks to an intimate coupling between the conformational plasticity of their bulky side chains and the number of bound Cu(I) ions. Namely, the Met residues act as a gate reducing the Cu(I) import rate when two ions simultaneously bind to CTR1. This may represent an elegant autoregulatory mechanism through which CTR1 protects the cells from excessively high, and hence toxic, in-cell Cu(I) levels. Overall, our outcomes resolve fundamental questions in CTR1 biology and open new windows of opportunity to tackle diseases associated with an imbalanced copper uptake.
Ključne besede: copper, membrane transporter, molecular dynamics, QM/MM, free energy
Objavljeno: 15.09.2022; Ogledov: 86; Prenosov: 0
.pdf Polno besedilo
Ogledov v tednu: 44

Kaj prinaša znanosti novi zakon?
Andreja Gomboc, 2022

Ključne besede: financiranje znanosti, zakoni, raziskave
Objavljeno: 21.09.2022; Ogledov: 44; Prenosov: 1
.pdf Polno besedilo
Ogledov v tednu: 44

Frontiers in cellular and infection microbiology

Objavljeno: 14.09.2022; Ogledov: 85; Prenosov: 2
URL Polno besedilo
Ogledov v tednu: 41